منابع مشابه
Regulatory T-lymphocytes in asthma.
T-helper cell type (Th)2 lymphocytes play an important role in the initiation, progression and persistence of allergic diseases, including asthma. However, little is known about immunoregulatory mechanisms that determine susceptibility to, severity of, or persistence of asthma. The concept of a disturbed Th1/Th2 balance, although having furthered the present understanding of immunoregulation in...
متن کاملRegulatory T Lymphocytes
Since Gowans first discovered the importance of lymphocytes in the immune response [1], a gradual understanding of their biology has evolved. Initially, B lymphocytes, the effector cells of humoral immunity, were studied in great detail. Largely because of the ability to obtain huge quantities of homogeneous antibodies-the B cell's primary product-through the study of multiple myeloma, tremendo...
متن کاملT Lymphocytes: Regulatory
CD4+ regulatory (Treg) T cells play a central role in the immune system by potently controlling the responses of other immunocytes. Their activity appears to be essential not only for themaintenanceof immunological self-tolerancebut potentially also for the control of all physiological immune responses whether against normal self-proteins, microbes or cancerous cells. A fuller understanding of ...
متن کاملthe role of t regulatory lymphocytes in lymphoma
t regulatory cells play a crucial role in immunological unresponsiveness to self- antigens and in suppressing excessive immune responses deleterious to the host. t regulatory cells are produced in the thymus as a functionally mature subpopulation of t cells. they can be induced from naive t cells in the periphery and express their marker as a forkhead/winged helix transcription factor called fo...
متن کاملRegulatory T cells in asthma.
Asthma is characterized by T helper cell 2 (Th2) type inflammation, leading to airway hyperresponsiveness and tissue remodeling. Th2 cell-driven inflammation is likely to represent an abnormal response to harmless airborne particles. These reactions are normally suppressed by regulatory T cells, which maintain airway tolerance. The anti-inflammatory cytokine IL-10 is likely to play a central ro...
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ژورنال
عنوان ژورنال: European Respiratory Journal
سال: 2005
ISSN: 0903-1936,1399-3003
DOI: 10.1183/09031936.05.00011205